Principles for Predicting RNA Secondary Structure Design Difficulty
نویسندگان
چکیده
منابع مشابه
Principles for Predicting RNA Secondary Structure Design Difficulty.
Designing RNAs that form specific secondary structures is enabling better understanding and control of living systems through RNA-guided silencing, genome editing and protein organization. Little is known, however, about which RNA secondary structures might be tractable for downstream sequence design, increasing the time and expense of design efforts due to inefficient secondary structure choic...
متن کاملNew Method for Predicting RNA Secondary Structure
It has become clear recently that there are many RNAs that are not translated into proteins, instead they work as functional molecules. These RNAs are called “non-coding RNAs.” Predicting the secondary structure of these RNAs is important for understanding their functions. We will therefore focus on Nussinov’s algorithm and the SCFG version of Nussinov’s algorithm as useful techniques for predi...
متن کاملMethod for predicting RNA secondary structure.
We report a method for predicting the most stable secondary structure of RNA from its primary sequence of nucleotides. The technique consists of a series of three computer programs interfaced to take the nucleotide sequence of any RNA and (a) list all possible helical regions, using modified Watson-Crick base-pairing rules; (b) create all possible secondary structures by forming permutations of...
متن کاملRNA secondary structure design.
We consider the inverse-folding problem for RNA secondary structures: for a given (pseudo-knot-free) secondary structure we want to find a sequence that has a certain structure as its ground state. If such a sequence exists, the structure is called designable. We have implemented a branch-and-bound algorithm that is able to do an exhaustive search within the sequence space, i.e., gives an exact...
متن کاملA New Method for Predicting RNA Secondary Structure
It has become clear recently that there are many RNAs that are not translated into proteins, instead they work as functional molecules. These RNAs are called “non-coding RNAs.” Predicting the secondary structure of these RNAs is important for understanding their functions. We focus on Nussinov’s algorithm and the SCFG version of Nussinov’s algorithm as useful techniques for predicting RNA secon...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2016
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2015.11.013